Stimulation of Adenosine A2A Receptor Regulates Peroxisome Proliferator Activated Receptors in Macrophages

Peroxisome Proliferator-activated Receptors

Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-activated nuclear hormone receptor superfamily of transcription factors that includes receptors for steroids, thyroid hormone, retinoic acid, and vitamin D. Upon activation in the cytoplasm, PPARs heterodimerize with retinoid X receptors (RXR) and form a complex that translocates to the nucleus and regulates gene expr...

Peroxisome Proliferator-Activated Receptor

Peroxisome proliferator - activated receptor

The peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. The discovery of PPARγ as a target of multimodal insulin sensitizers has attracted remarkable scientific interest and had a great impact on the pharmaceutical industry. Thi...

Peroxisome Proliferator-Activated Receptor

Peroxisome Proliferator-Activated Receptor Reduces Cholesterol Esterification in Macrophages

Peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor activated by fatty acid derivatives and hypolipidemic drugs of the fibrate class. PPAR is expressed in monocytes, macrophages, and foam cells, suggesting a role for this receptor in macrophage lipid homeostasis with consequences for atherosclerosis development. Recently, it was shown that PPAR activation promotes cholester...